Osteoinductive factor as a significant marker for the diagnosis of early diabetic nephropathy

Background: The main factor causing chronic kidney disease, which progressively leads to end-stage renal failure, is diabetic nephropathy (DN). This study aims shed light on the importance of osteo-inductive (OIF) as a sensitive indicator for early identification DN Methods: On 80 participants, this prospective cohort observational research was conducted. A total 60 them had diabetes mellitus type 2 based ADA 2019 guidelines. Four equal groups patients were created: 20 healthy people made up group 1 (control group), followed by with normo-albuminuria in 2, micro-albuminuria 3, and macro-albuminuria 4.Results: substantial elevation OIF existed 3 compared while there no variations among 2. directly proportionate degree albuminuria. There important positive relation between HbA1c %, fasting blood glucose, hours post prandial serum creatinine, urea, urine albumin / creatinine ratio, cholesterol, TG Low density lipoproteins, negative correlation both glomerular filtration rate high-density lipoprotein. significant predictor detection microalbuminuria (Area under curve (AUC) 0.869 p=0.014) at cut-off 9.0 86.7% sensitivity 95% specificity.Conclusions: increases progression nephropathy, also marker can be considered good nephropathy.